Transcriptomics

Dataset Information

0

Protein Tyrosine Phosphatase UBASH3B is Overexpressed in Triple-Negative Breast Cancer and Promotes Invasion and Metastasis


ABSTRACT: Efforts to improve the clinical outcome of highly aggressive triple-negative breast cancer (TNBC) have been hindered by the lack of effective targeted therapies. Thus, it is important to identify the specific gene targets/pathways driving the invasive phenotype to develop more effective therapeutics. Here we show that ubiquitin-associated and SH3 domain-containing B (UBASH3B), a protein tyrosine phosphatase, is overexpressed in TNBC, where it supports malignant growth, invasion, and metastasis largely through modulating epidermal growth factor receptor (EGFR). We also show that UBASH3B is a functional target of anti-invasive microRNA200a (miR200a) that is down-regulated in TNBC. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity, which targets CBL ubiquitin ligase for dephosphorylation and inactivation, leading to EGFR up-regulation. Thus, UBASH3B may function as a crucial node in bridging multiple invasion-promoting pathways, thereby providing a potential therapeutic target for TNBC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE36693 | GEO | 2013/06/01

SECONDARY ACCESSION(S): PRJNA153615

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-06-01 | E-GEOD-36693 | biostudies-arrayexpress
2023-01-03 | GSE215069 | GEO
2021-09-10 | PXD024279 | Pride
2020-08-31 | GSE156676 | GEO
2015-04-06 | GSE59800 | GEO
2023-03-11 | PXD031988 | Pride
2017-06-05 | PXD006390 | Pride
2019-10-20 | GSE121176 | GEO
2022-04-15 | PXD021307 | Pride
2016-03-25 | GSE67301 | GEO