Transcriptomics

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RBFOX1 Splicing and Transcriptional Regulation in Neurons


ABSTRACT: We used RNA sequencing to identify the RBFOX1 splicing network at a genome-wide level in primary human neural stem cells during differentiation. We observe that RBFOX1 regulates a large set of alternative splicing events implicated in neurogenesis and cell maintenance. Subsequent alterations in gene expression define an additional transcriptional network regulated by RBFOX1 involved in neurodevelopmental pathways remarkably parallel to those affected by splicing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE36710 | GEO | 2012/06/29

SECONDARY ACCESSION(S): PRJNA153783

REPOSITORIES: GEO

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