Tobacco smoke exposure-related pathway gene expression signature in the bronchial airway epithelium
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ABSTRACT: Using primary human bronchial epithelial cells collected at bronchoscopy, we have perturbed signaling pathways important in regulation of response to tobacco smoke exposure and cancer development: ATM, BCL2, GPX1, NOS2, IKBKB, and SIRT1 Using gene expression profiles generated for each pathway and four independent gene expression datasets, we show that SIRT1 activity is significantly up-regulated in cytologically normal airway epithelial cells from active smokers compared to non-smokers; and in contrast, this activity is strikingly down-regulated in non-small cell lung cancer.
ORGANISM(S): Homo sapiens
PROVIDER: GSE37058 | GEO | 2012/09/27
SECONDARY ACCESSION(S): PRJNA158397
REPOSITORIES: GEO
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