Transcriptomics

Dataset Information

0

Oncogenic BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration [Affymetrix]


ABSTRACT: Most cancer genomics papers to date have focused on aberrations in genomic DNA and protein-coding transcripts. However, around 50% of transcripts have no coding potential and may exist as non-coding RNA. We performed RNA-seq in BRAFv600e melanoma skin cancer and on melanocytes over-expressing oncogenic BRAF to catalog transcriptome remodeling. We discovered that BRAF regulates expression of 1027 protein coding transcripts, 39 annotated lncRNAs and 70 novel transcripts. Many of the novel transcripts are lncRNAs. We used an indepenedent dataset to interrogate our novel transcripts and found that the novel lncRNA BANCR is a BRAF-regulated lncRNA recurrently upregulated in melanoma. Knockdown of BANCR impairs melanoma cell migration.

ORGANISM(S): Homo sapiens

PROVIDER: GSE37132 | GEO | 2012/04/28

SECONDARY ACCESSION(S): PRJNA158409

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-04-27 | E-GEOD-37132 | biostudies-arrayexpress
2012-04-28 | E-GEOD-33092 | biostudies-arrayexpress
2012-04-28 | GSE33092 | GEO
2017-09-05 | GSE90044 | GEO
2020-01-09 | PXD014553 | Pride
2014-06-24 | E-GEOD-58755 | biostudies-arrayexpress
2011-08-14 | E-GEOD-31021 | biostudies-arrayexpress
2024-09-05 | PXD055094 | Pride
2011-08-15 | GSE31021 | GEO
2013-06-30 | E-GEOD-38056 | biostudies-arrayexpress