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C-Myc is a universal amplifier of gene expression [Microarray]

ABSTRACT: The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism and differentiation at the cellular, tissue or organismal levels via regulation of numerous target genes. In part due to the incomplete inventory and functional accounting of Myc’s targets, no principle unifies Myc action. To relate the dynamics of Myc-binding with target expression and function in a system where Myc-levels are temporally and physiologically regulated, the transcriptomes and the genome-wide distributions of Myc, RNA polymerase II and chromatin modifications were compared during lymphocyte activation and in ES cells. A remarkably simple rule emerged from this quantitative analysis: Myc is not an on-off switch, but is a non-linear amplifier of expression, acting universally at active genes, except for immediate early genes that are strongly induced before Myc. This rule of Myc action explains the vast majority of Myc biology observed in literature.

ORGANISM(S): Mus musculus

PROVIDER: GSE37222 | GEO | 2012/09/27

SECONDARY ACCESSION(S): PRJNA159015

REPOSITORIES: GEO

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c-Myc is a universal amplifier of gene expression [ChIP-Seq]

Project description:The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism and differentiation at the cellular, tissue or organismal levels via regulation of numerous target genes. In part due to the incomplete inventory and functional accounting of Myc’s targets, no principle unifies Myc action. To relate the dynamics of Myc-binding with target expression and function in a system where Myc-levels are temporally and physiologically regulated, the transcriptomes and the genome-wide distributions of Myc, RNA polymerase II and chromatin modifications were compared during lymphocyte activation and in ES cells. A remarkably simple rule emerged from this quantitative analysis: Myc is not an on-off switch, but is a non-linear amplifier of expression, acting universally at active genes, except for immediate early genes that are strongly induced before Myc. This rule of Myc action explains the vast majority of Myc biology observed in literature.

2012-09-27 | GSE37229 | GEO

c-Myc is a universal amplifier of gene expression [Microarray]

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2012-09-27 | E-GEOD-37229 | biostudies-arrayexpress

c-Myc is a universal amplifier of gene expression

Project description:This SuperSeries is composed of the following subset Series: GSE37222: c-Myc is a universal amplifier of gene expression [Microarray] GSE37229: c-Myc is a universal amplifier of gene expression [ChIP-Seq] Refer to individual Series

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c-Myc is a universal amplifier of gene expression

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RNA clamping by Vasa assembles a piRNA Amplifier complex on transposon transcripts

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RNA clamping by Vasa assembles a piRNA Amplifier complex on transposon transcripts

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Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy

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Project description:c-Myc is a universal amplifier of gene expression

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