Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spleen, B Cell
DISEASE(S): Burkitt Lymphoma
SUBMITTER: John Koomen
LAB HEAD: John Cleveland
PROVIDER: PXD031361 | Pride | 2024-01-26
REPOSITORIES: Pride
Items per page: 1 - 5 of 121 |
Blood cancer discovery 20230701 4
The MYC oncoprotein is activated in a broad spectrum of human malignancies and transcriptionally reprograms the genome to drive cancer cell growth. Given this, it is unclear if targeting a single effector of MYC will have therapeutic benefit. MYC activates the polyamine-hypusine circuit, which posttranslationally modifies the eukaryotic translation factor eIF5A. The roles of this circuit in cancer are unclear. Here we report essential intrinsic roles for hypusinated eIF5A in the development and ...[more]