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Effect of small molecules on activated astrocytes

ABSTRACT: We have developed an assay to test the neuroprotective properties of compounds using stem cell–derived motor neurons and astrocytes, together with activated microglia as a stress paradigm. Hit compounds were discovered and the transcriptional response on activated astrocytes cells was tested.

ORGANISM(S): Mus musculus

PROVIDER: GSE37611 | GEO | 2012/11/03

SECONDARY ACCESSION(S): PRJNA162319

REPOSITORIES: GEO

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Effect of small molecules on activated astrocytes

Project description:We have developed an assay to test the neuroprotective properties of compounds using stem cellM-bM-^@M-^Sderived motor neurons and astrocytes, together with activated microglia as a stress paradigm. Hit compounds were discovered and the transcriptional response on activated astrocytes cells was tested. Neural stem cell (NSC)-derived astrocytes (AC) were activated with LPS and IFN-M-NM-3 and treated with hit compound for 4 hr.

2012-11-03 | E-GEOD-37611 | biostudies-arrayexpress

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Effect of small molecules on activated astrocytes and microglia cells

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