Genotoxic alterations of cord blood cells in newborns exposed in utero to a zidovudine-based antiretroviral combination
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ABSTRACT: Background: Zidovudine remains the cornerstone drug for prophylaxis to prevent mother-to-child HIV-1 transmission. A mild but long-lasting hematological multilineage defect is observed in children exposed in utero. Objectives: To evaluate the effects of zidovudine-based ARV combinations on newborn cord blood cells. Methods: Cord blood-derived mononuclear cells from 22 HIV-1-uninfected newborn exposed in utero to a zidovudine-based ARV combination and from 20 healthy unexposed newborn were investigated by immunophenotyping, gene expression analysis, cytogenetic studies and functional capacity testing.
ORGANISM(S): Homo sapiens
PROVIDER: GSE37748 | GEO | 2012/05/03
SECONDARY ACCESSION(S): PRJNA163075
REPOSITORIES: GEO
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