Transcriptomics

Dataset Information

0

VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet beta cell survival and function survival and function


ABSTRACT: Deterioration of functional islet β-cell mass is the final step in progression to Type 2 diabetes. We previously reported that overexpression of Nkx6.1 in rat islets has the dual effects of enhancing glucose-stimulated insulin secretion (GSIS) and increasing β-cell replication. Here we show that Nkx6.1 strongly upregulates the prohormone VGF in rat islets and that VGF is both necessary and sufficient for Nkx6.1-mediated enhancement of GSIS. Moreover, the VGF-derived peptide TLQP-21 potentiates GSIS in rat and human islets and improves glucose tolerance in vivo. Chronic injection of TLQP-21 in pre-diabetic ZDF rats preserves islet mass and slows diabetes onset. TLQP-21 prevents islet cell apoptosis by a pathway similar to that used by GLP-1, but independent of the GLP-1, GIP, or VIP receptors. Unlike GLP-1, TLQP-21 does not inhibit gastric emptying or increase heart rate. We conclude that a TLQP-21 is a novel agent for enhancing islet β-cell survival and function.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE37852 | GEO | 2012/05/10

SECONDARY ACCESSION(S): PRJNA165161

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-05-09 | E-GEOD-37852 | biostudies-arrayexpress
2008-10-11 | GSE13153 | GEO
2010-05-18 | E-GEOD-13153 | biostudies-arrayexpress
2014-02-18 | E-GEOD-55077 | biostudies-arrayexpress
2013-09-01 | GSE49786 | GEO
2013-09-01 | E-GEOD-49786 | biostudies-arrayexpress
2018-08-19 | GSE118230 | GEO
2014-02-18 | E-GEOD-55078 | biostudies-arrayexpress
2017-10-18 | GSE100660 | GEO
2014-02-18 | GSE55077 | GEO