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Gene Expression Comparison of First Passage vs. Primary Human and Mouse Retinal Sphere Cells

ABSTRACT: The pigmented portion of ciliary epithelium in the adult mammalian eye harbors mitotically quiescent retinal sphere cells, which are capable of self-renewal and differentiating into retinal neurons when assayed in vitro; however, very little is known about the molecular mechanism controlling the proliferation and differentiation of these adult retinal stem cells or their molecular resemblance to mutipotent stem/progenitor cells during early eye development. This experiment studies the gene expression of first passage and primary human and mouse retinal sphere cells. Keywords: other

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE3791 | GEO | 2005/12/09

SECONDARY ACCESSION(S): PRJNA93989

REPOSITORIES: GEO

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Transcription profiling of human and mouse first passage vs. primary retinal sphere cells

Project description:The pigmented portion of ciliary epithelium in the adult mammalian eye harbors mitotically quiescent retinal sphere cells, which are capable of self-renewal and differentiating into retinal neurons when assayed in vitro; however, very little is known about the molecular mechanism controlling the proliferation and differentiation of these adult retinal stem cells or their molecular resemblance to mutipotent stem/progenitor cells during early eye development. This experiment studies the gene expression of first passage and primary human and mouse retinal sphere cells. Experiment Overall Design: this experiment include 4 samples and 12 replicates

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