Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Donor-dependent hepatic differentiation propensity among hiPSC lines.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE38155 | GEO | 2012/07/16

SECONDARY ACCESSION(S): PRJNA167453

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Donor-dependent hepatic differentiation propensity among hiPSC lines.

Project description:This SuperSeries is composed of the following subset Series: GSE38152: sibling aHDF-iPSC clones derived from the same fibroblasts GSE38153: aHDF- and PB-iPSC clones from the same individuals Refer to individual Series

2012-07-15 | E-GEOD-38155 | biostudies-arrayexpress

Hepatitis C virus-induced expression profiling of Hepatic and non-hepatic cancer cell lines

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-07-10 | E-GEOD-70781 | biostudies-arrayexpress

Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-03-02 | E-GEOD-76292 | biostudies-arrayexpress

RNA-Seq Versus Oligonucleotide Array Assessment of Dose-Dependent TCDD-elicited Hepatic Gene Expression in Mice

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-02-10 | E-GEOD-62903 | biostudies-arrayexpress

Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells.

Project description:Hepatocytes generated from human induced pluripotent stem cells (hiPSCs) are unprecedented resources for pharmaceuticals and cell therapy. However, the in vitro directed differentiation of human pluripotent stem cells into mature hepatocytes remains challenging. Little attention has so far been paid to variations among hiPSC lines in terms of their hepatic differentiation. In the current study, we developed an improved hepatic differentiation protocol and compared 28 hiPSC lines originated from various somatic cells and derived using retroviruses, Sendai viruses, or episomal plasmids. This comparison indicated that the origins, but not the derivation methods, may be a major determinant of variation in hepatic differentiation. The hiPSC clones derived from peripheral blood cells consistently showed good differentiation efficiency, whereas many hiPSC clones from adult dermal fibroblasts showed poor differentiation. However, when we compared hiPSCs from peripheral blood and dermal fibroblasts from the same individuals, we found that variations in hepatic differentiation were largely attributable to donor differences, rather than to the types of the original cells. These data underscore the importance of donor differences when comparing the differentiation propensities of hiPSC clones.

| S-EPMC3411998 | biostudies-literature

Dnmt3L-dependent regulation of DNA methylation promotes stem cells differentiation toward primitive germinal cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-09-27 | E-GEOD-44644 | biostudies-arrayexpress

Hepatitis C virus-induced expression profiling of Hepatic and non-hepatic cancer cell lines

Project description:This SuperSeries is composed of the SubSeries listed below.

2015-07-10 | GSE70781 | GEO

Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-06-08 | E-GEOD-47733 | biostudies-arrayexpress

Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines.

Project description:Hematopoiesis generated from human embryonic stem cells (ES) and induced pluripotent stem cells (iPS) are unprecedented resources for cell therapy. We compared hematopoietic differentiation potentials from ES and iPS cell lines originated from various donors and derived them using integrative and non-integrative vectors. Significant differences in differentiation toward hematopoietic lineage were observed among ES and iPS. The ability of engraftment of iPS or ES-derived cells in NOG mice varied among the lines with low levels of chimerism. iPS generated from ES cell-derived mesenchymal stem cells (MSC) reproduce a similar hematopoietic outcome compared to their parental ES cell line. We were not able to identify any specific hematopoietic transcription factors that allow to distinguish between good versus poor hematopoiesis in undifferentiated ES or iPS cell lines. There is a relatively unpredictable variation in hematopoietic differentiation between ES and iPS cell lines that could not be predicted based on phenotype or gene expression of the undifferentiated cells. These results demonstrate the influence of genetic background in variation of hematopoietic potential rather than the reprogramming process.

| S-EPMC4777368 | biostudies-literature

Modulation of gene expression by rapamycin in hepatic cell lines

Project description:This SuperSeries is composed of the SubSeries listed below.

2009-09-20 | GSE17677 | GEO