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Transcriptional profiling of Rapamycin-treated ptc6 and ptc1ptc6 mutant yeast cells

ABSTRACT: We are interested in the study of the sensitivity of yeast cells lacking either the type 1 protein phosphatase Ptc6 or Ptc1 and Ptc6 to the drug rapamycin. In order to carry out our studies, we analyzed the changes in the transcription profile that a short-term incubation with rapamycin (200 ng/mL) has in wild type, ptc6 mutant and ptc1 ptc6 double mutant cells. It has been shown that inhibition of the TOR pathway by treatment with rapamycin has profound effects on the global transcriptional profile. We confirmed the previously described transcription changes induced by the drug in wild type cells and characterized an notable attenuation of the transcriptional response in cells lacking either PTC6 or PTC1 and PTC6 genes.

ORGANISM(S): Saccharomyces cerevisiae

PROVIDER: GSE38256 | GEO | 2013/04/19

SECONDARY ACCESSION(S): PRJNA167590

REPOSITORIES: GEO

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Transcriptional profiling of Rapamycin treatment in yeast cells lacking the Ptc1 protein phosphatase.

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