Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Gene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE39104 | GEO | 2013/01/08

SECONDARY ACCESSION(S): PRJNA170015

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Gene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-01-08 | E-GEOD-39104 | biostudies-arrayexpress

Gene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [Lin]

Project description:The transcription factor Evi1 is essential for the formation and maintenance of hematopoietic stem cells, and induces clonal dominance with malignant progression upon constitutive activation by chromosomal rearrangements or transgene integration events. To understand the immediate and adaptive response of primary murine hematopoietic cells to the transcriptional upregulation of Evi1, we developed an inducible lentiviral vector system with a robust expression switch. We found that Evi1 delays differentiation and promotes survival in myeloid culture conditions, orchestrating a battery of genes involved in stemness (Aldh1a1, Ly6a [Sca1], Abca1, Epcam, among others). Importantly, Evi1 suppresses Cyclins and Cyclin-dependent kinases (Cdk), while it upregulates Cdk inhibitors, inducing quiescence in various proliferation-inducing cytokine conditions and operating in a strictly dose-dependent manner. Hematopoietic cells with persisting Evi1-induction tend to adopt a relatively low expression level. We thus classify Evi1 as a dormancy-inducing oncogene, likely requiring epigenetic and genetic compensation for cell expansion and malignant progression.

2013-01-09 | GSE34729 | GEO

Gene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [Lin]

2013-01-09 | E-GEOD-34729 | biostudies-arrayexpress

Gene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [EVI1_ST]

2013-01-08 | GSE39103 | GEO

Gene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [EVI1_ST]

2013-01-08 | E-GEOD-39103 | biostudies-arrayexpress

Epigenetic and genetic changes during mouse hematopoietic stem cell aging

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-04-30 | E-GEOD-47819 | biostudies-arrayexpress

Formaldehyde-induced changes in microRNA signaling

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series