Transcriptomics

Dataset Information

0

Targeting PyMT oncogene to diverse mammary cell populations enhances tumor heterogeneity and generates rare breast cancer subtypes


ABSTRACT: We are generating a new mouse model for breast cancer heterogenaity using lentiviral infection to integrate the sporatically transforming EF1α-PyMT10C or Muc-PyMT10C lentivirus into mouse mammary epithelial cell genomes. We then transplant those cells into cleared mammary fat pads of recipient mice, allowing tumors to develop from luminal , myoepithelial, stem and progenitor cell lineages. We developed a wide variety of tumors including rare histologies such as squamous, tubular, spindloid and lipid rich. We used microarray analysis to compare our mouse model with a microarray analysis of 9 established mouse models (Herschkowitz, J.I. et al. Genome Biology, 2007). Heirarchal clustering was used to establish the molecular subtype of tumors developed through the lentiviral-PyMT mouse model. In addition, micrarray analysis was used in conjunction with GeneSifter and GO ontology to identify unique pathways for each of the rare tumor types.

ORGANISM(S): Mus musculus

PROVIDER: GSE40001 | GEO | 2012/08/10

SECONDARY ACCESSION(S): PRJNA172249

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2012-08-09 | E-GEOD-40001 | biostudies-arrayexpress
2011-08-14 | E-GEOD-27101 | biostudies-arrayexpress
2011-08-15 | GSE27101 | GEO
2011-12-05 | E-GEOD-34146 | biostudies-arrayexpress
2020-09-07 | PXD019255 | Pride
2011-12-05 | GSE34146 | GEO
2018-01-01 | GSE107923 | GEO
2018-02-22 | GSE77096 | GEO
| PRJNA323509 | ENA
2023-10-16 | GSE214433 | GEO