Methylation profiling

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Non-CpG island promoter hypomethylation and miR-149 regulate the expression of SRPX2 in colorectal cancer

ABSTRACT: We used Illumina Infinium 27k Human DNA Methylation BeadChip v1.2 to assess genome-wide DNA methylation profiling of normal colon epithelial, adenomas and colorectal adenocarcinomas across approximately 27,000 CpGs in fresh frozen colorectal tissue samples. We found that cancer-associated methylation changes with impact on transcription occur nearly as frequent at non-CpG island as CpG island promoters in colorectal cancer (CRC).

ORGANISM(S): Homo sapiens

PROVIDER: GSE40055 | GEO | 2013/06/15

SECONDARY ACCESSION(S): PRJNA172726

REPOSITORIES: GEO

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