Genomics

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Constitutional Trisomy 8 Mosaicism as a Model for Epigenetic Studies of Aneuploidy (microRNA)


ABSTRACT: To increase our understanding of epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient. We profiled gene and miRNA expression as well as genome-wide and promoter specific DNA methylation and hydroxymethylation patterns in trisomic and disomic fibroblasts, using microarrays and methylated DNA immunoprecipitation.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE40319 | GEO | 2012/12/01

SECONDARY ACCESSION(S): PRJNA173494

REPOSITORIES: GEO

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