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MicroRNA-449a Enhances Radiosensitivity in Lung Adenocarcinoma Cells

ABSTRACT: Twenty-five miRNAs were identified as having differential expression post-irradiation in CL1-0 or CL1-5 cells. Among these miRNAs, miR-449a, which was down-regulated in CL1-0 cells at 24 h after irradiation, was chosen for further investigation. Overexpression of miR-449a in CL1-0 cells effectively increased irradiation-induced DNA damage and apoptosis, altered the cell cycle distribution and eventually led to sensitization of CL1-0 to irradiation. MiR-449a might be a novel radiosensitizer for clinical applications.

ORGANISM(S): Homo sapiens

PROVIDER: GSE40602 | GEO | 2012/12/30

SECONDARY ACCESSION(S): PRJNA174365

REPOSITORIES: GEO

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MicroRNA-449a Enhances Radiosensitivity in Lung Adenocarcinoma Cells

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