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SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

ABSTRACT: Comparing the host response of C57BL/6J mice to Tnfrsf1a/1b knockouts in the same strain of mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE40840 | GEO | 2012/09/13

SECONDARY ACCESSION(S): PRJNA175064

REPOSITORIES: GEO

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SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

Project description:Comparing the host response of C57BL/6J mice to Tnfrsf1a/1b knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or Tnfrsf1a/1b knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

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