Transcriptomics

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Gene expression profiles induced by shRNA-mediated knockdown of PDEF in MCF7 mammary epithelial cell line


ABSTRACT: Microarray gene expression analysis was performed in MCF7 cells transduced with a non-specific shRNA or PDEF-targeting shRNA, and both subjected to hormone depletion for 48 hours. Analyses of differentially expressed genes combined with gene ontology revealed a downregulation of cell cycle related-genes and an upregulation of apoptosis-related genes in PDEF knockdown cells. These target genes constitute potential effectors of the pro-survival role of PDEF.

ORGANISM(S): Homo sapiens

PROVIDER: GSE40985 | GEO | 2014/03/29

SECONDARY ACCESSION(S): PRJNA175497

REPOSITORIES: GEO

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