Effect of ionizing radiation on procoagulant activity
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ABSTRACT: Ionizing radiation (IR) is associated with thrombotic vascular occlusion. Thrombosis in malignancy predicts a poor clinical outcome. Tissue factor (TF) is the initiator of the extrinsic co-agulation system and induces thrombus formation. Our study examined whether IR induced TF expression and procoagulability in the myelomonocytic leukemia THP-1 cell model. We further investigated coordinated gene alterations associated with TF upregulation and IR-induced thrombogenicity. Gene expression profiling revealed IR to increase the expression of inflammatory and apoptosis-related pathways, contributing to TF upregulation and increased TF procoagulability on day 7 post IR. The upregulation of these pathways together with TF upregulation contributed to the increased thrombogenic potential of tissues post application of IR. Keywords: irridiation response
ORGANISM(S): Homo sapiens
PROVIDER: GSE4110 | GEO | 2006/01/29
SECONDARY ACCESSION(S): PRJNA94931
REPOSITORIES: GEO
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