Dataset Information

Reduced thrombogenicity of surface-treated Nitinol implants steered by altered protein adsorption

ABSTRACT: Blood-contacting medical implants made of Nitinol and other titanium alloys, such as neurovascular flow diverters and peripheral stents, have the disadvantage of being highly thrombogenic. This makes the use of systemic (dual) anti platelet / anticoagulant therapies inevitable with related risks of device thrombosis, bleeding and other complications. Meeting the urgent clinical demand for a less thrombogenic Nitinol surface, we describe here a treatment of standard, commercially available Nitinol that renders its surface ultra-hydrophilic and functionalized with phosphate ions. The efficacy of this treatment was assessed by comparing standard and surface-treated Nitinol disks and braids, equivalent to flow diverters. Static and dynamic (Chandler loop) blood incubation tests showed a drastic reduction of thrombus formation on treated devices. Surface chemistry and proteomic analysis indicated a key role of phosphate and calcium ions in steering blood protein adsorption and avoiding coagulation cascade activation and platelet adhesion. A good endothelialization of the surface confirmed the biocompatibility of the treated surface.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Katharina Gegenschatz

LAB HEAD: Martin Ehrbar

PROVIDER: PXD024284 | Pride | 2022-01-13

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20190806_002_S201785_D_20190805_BT_NaCl_untreated.raw	Raw
	20190806_003_S201787_QDST_20190805_B_Hanks_treated.raw	Raw
	20190806_004_S201780_D_20190805_B_NaCl_untreated.raw	Raw
	20190806_007_S201791_QDST_20190805_CF_Hanks_treated.raw	Raw
	20190806_009_S201783_D_20190805_CF_NaCl_untreated.raw	Raw

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Publications

Reduced thrombogenicity of surface-treated Nitinol implants steered by altered protein adsorption.

Gegenschatz-Schmid Katharina K Buzzi Stefano S Grossmann Jonas J Roschitzki Bernd B Urbanet Riccardo R Heuberger Roman R Glück Dorothea D Zucker Arik A Ehrbar Martin M

Acta biomaterialia 20211019

Blood-contacting medical implants made of Nitinol and other titanium alloys, such as neurovascular flow diverters and peripheral stents, have the disadvantage of being highly thrombogenic. This makes the use of systemic (dual) anti-platelet/anticoagulant therapies inevitable with related risks of device thrombosis, bleeding and other complications. Meeting the urgent clinical demand for a less thrombogenic Nitinol surface, we describe here a simple treatment of standard, commercially available N ...[more]

PMID: 34673227

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