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Effect of PRR15 knockdown on human trophoblast cell gene expression

ABSTRACT: Proline rich 15 (PRR15) is a small nuclear protein required for normal conceptus development in the sheep. We used microarrays to assess the changes in the trophoblast transcriptome when PRR15 expression was diminished.

ORGANISM(S): Homo sapiens

PROVIDER: GSE41459 | GEO | 2012/10/11

SECONDARY ACCESSION(S): PRJNA177068

REPOSITORIES: GEO

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Effect of PRR15 knockdown on human trophoblast cell gene expression

Project description:Proline rich 15 (PRR15) is a small nuclear protein required for normal conceptus development in the sheep. We used microarrays to assess the changes in the trophoblast transcriptome when PRR15 expression was diminished. The human first-trimester trophoblast cell line, ACH-3P, was infected with control lentivirus expressing no shRNA or lentivirus expressing shRNA to target PRR15 mRNA for degradation, with three biological replicates per treatment.

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