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Expression data from ALK over-expressed MCF-7 clones and control clones

ABSTRACT: To evaluate the function of ALK in breast cancer, we enforcing expressed full length wild type ALK in the parental MCF-7 breast cancer cell line that we have established in previous studies have a very low invasive capacity, do not form tumor emboli nor do they invade into the dermal lymphatics when grown as xenografts.

ORGANISM(S): Homo sapiens

PROVIDER: GSE41635 | GEO | 2012/10/17

SECONDARY ACCESSION(S): PRJNA177775

REPOSITORIES: GEO

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Expression data from ALK over-expressed MCF-7 clones and control clones

Project description:To evaluate the function of ALK in breast cancer, we enforcing expressed full length wild type ALK in the parental MCF-7 breast cancer cell line that we have established in previous studies have a very low invasive capacity, do not form tumor emboli nor do they invade into the dermal lymphatics when grown as xenografts. Whole unbiased transcriptome analysis were performed using ALK over-expressed MCF-7 clones and control clones. Pathway mapping revealed that the presence of ALK induced up and down regulation changes of series of genes within several canonical signal pathway.

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Expression data from ALK over-expressed MCF-7 clones and control clones

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Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status, ALK mRNA and protein levels.

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