MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells
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ABSTRACT: Gene expression profiling was carried out in Huh-7.5 cells in which miR-27a was over- or under-expressed. Transfection of cells with pre-miR-27a and pre-miR-control, or anti-miR-27a and anti-miR-control enabled down- and up-regulated genes to be determined, respectively. Replication and infectivity of the lipotrophic hepatitis C virus (HCV) is regulated by cellular lipid status. Among differentially expressed micro (mi)RNAs, we found that miR-27a was preferentially expressed in HCV-infected compared with hepatitis B virus (HBV)-infected liver. Gene expression profiling of Huh-7.5 cells showed that miR-27a regulates lipid metabolism by targeting the lipid synthetic transcriptional factor, RXRα, and the lipid transporter, ABCA1
ORGANISM(S): Homo sapiens
PROVIDER: GSE41737 | GEO | 2013/06/05
SECONDARY ACCESSION(S): PRJNA178094
REPOSITORIES: GEO
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