Transcriptomics

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Reduced inflammatory response under candesartan pre-treatment following transient focal ischemia in rats


ABSTRACT: Large clinical studies have shown that AT1 receptor blockers (ARBs) reduce the incidence of stroke in patients at risk. However, there is controversy about the underlying pathomechanisms. To get a closer insight into the effects of ARBs in stroke on molecular level, gene expression pattern was compared in the ischemic brain areas of Candesartan pre-treated (0,2 mg/kg bwt., 5 days, s.c.) versus vehicle treated, normotensive, adult rats after middle carotid artery occlusion (MCAO). Candesartan significantly improved neurological outcome (as estimated by Garcia-scale) 24 h and 48 h after stroke and reduced infarct volume by about 40% compared to vehicle. Keywords: disease state analysis

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE4206 | GEO | 2006/12/31

SECONDARY ACCESSION(S): PRJNA95063

REPOSITORIES: GEO

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