Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
DISEASE(S): hypertensive
SUBMITTER: Juan Saavedra
PROVIDER: E-GEOD-2739 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Stroke 20060406 5
<h4>Background and purpose</h4>Blockade of angiotensin II AT1 receptors in cerebral microvessels protects against brain ischemia and inflammation. In this study, we tried to clarify the presence and regulation of the local renin-angiotensin system (RAS) in brain microvessels in hypertension.<h4>Methods</h4>Spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) controls were treated with an AT1 receptor antagonist (candesartan, 0.3 mg/kg per day) via subcutaneous osmotic minipumps for 4 wee ...[more]