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Transcription profiling of hypertensive and normotensive rats treated with the AT1 receptor antagonist candesartan and vehicle

ABSTRACT: In hypertension, abnormal regulation of microcirculation and endothelial dysfunction enhances vulnerability to hypertensive brain damage. In addition to lowering blood pressure, blockade of Angiotensin II AT1 receptors protects against stroke and stress in different animal models and this treatment may be of therapeutic advantage. We studied gene expression using Affymetrix Rat Genome U34A arrays from brain microvessels of spontaneously hypertensive rats (SHR) and their normotensive Wistar Kyoto controls (WKY) rats treated with an AT1 antagonist (candesartan, 0.3 mg/kg/day) or vehicle via osmotic minipumps for 4 weeks. Experiment Overall Design: brain microvessels from hypertensive and normotensive rats treated with candesartan and vehicle were analyzed

ORGANISM(S): Rattus norvegicus

DISEASE(S): hypertensive

SUBMITTER: Juan Saavedra

PROVIDER: E-GEOD-2739 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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AT1 receptor blockade regulates the local angiotensin II system in cerebral microvessels from spontaneously hypertensive rats.

Zhou Jin J Pavel Jaroslav J Macova Miroslava M Yu Zu-Xi ZX Imboden Hans H Ge Linna L Nishioku Tsuyoshi T Dou Jingtao J Delgiacco Elizabeth E Saavedra Juan M JM

Stroke 20060406 5

<h4>Background and purpose</h4>Blockade of angiotensin II AT1 receptors in cerebral microvessels protects against brain ischemia and inflammation. In this study, we tried to clarify the presence and regulation of the local renin-angiotensin system (RAS) in brain microvessels in hypertension.<h4>Methods</h4>Spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) controls were treated with an AT1 receptor antagonist (candesartan, 0.3 mg/kg per day) via subcutaneous osmotic minipumps for 4 wee ...[more]

PMID: 16601219

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