Genomics

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ChIP-seq analysis of Gli1 and Sox2 input to neural progenitor program and integration with actve histone marks


ABSTRACT: In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentration-dependent induction of six different cell populations mediated through Gli transcriptional regulators. Elsewhere in the embryo, Shh/Gli responses invoke different tissue appropriate regulatory programs. To elucidate Shh/Gli regulation of neural fate sepcification, we performed Gli1 ChIP-Seq analysis. We further analyzed two transcription factors whose motifs were enriched in Gli1 ChIP data (Sox2 and Foxa2). Two active histone marks (H3K4me2 and H3K27ac) were additionally analyzed to study activity status of Shh-responsive cis-elements.

ORGANISM(S): Mus musculus

PROVIDER: GSE42132 | GEO | 2012/12/15

SECONDARY ACCESSION(S): PRJNA179206

REPOSITORIES: GEO

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