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Effect of cigarette smoke extract, cisplatin, nicotine and/or ionizing radiation on gene expression in the NCI-H460 human lung large cell carcinoma cell line

ABSTRACT: To understand the effect of nicotine on sensitivity of cancer cells to radiation or anti-cancer drugs, NCI-H460 human lung large cell carcinoma cells were treated with 6 Gy ionizing radiation or 1 uM cisplatin after exposure to 5 uM nicotine or cigarette smoke extract. Whole genome expression in total RNA extracted from the treated cells was quantified using the GeneChip™ Human Gene 1.0 ST microarray platform from Affymetrix® (Santa Clara, CA).

ORGANISM(S): Homo sapiens

PROVIDER: GSE42172 | GEO | 2014/12/31

SECONDARY ACCESSION(S): PRJNA179230

REPOSITORIES: GEO

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