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Effect of cigarette smoke extract, cisplatin, nicotine and/or ionizing radiation on microRNA expression in the NCI-H460 human lung large cell carcinoma cell line

ABSTRACT: To understand the effect of nicotine on sensitivity of cancer cells to radiation or anti-cancer drugs, NCI-H460 human lung large cell carcinoma cells were treated with 6 Gy ionizing radiation or 1 uM cisplatin after exposure to 0.5 uM nicotine or cigarette smoke extract. MicroRNA expression in total RNA extracted from the treated cells was quantified using the 7th generation miRCURY™ locked nucleic acid microarray platform from Exiqon® (Vedbaek, Denmark).

ORGANISM(S): Merkel cell polyomavirus Cytomegalovirus Lymphocryptovirus JC polyomavirus Betapolyomavirus macacae Homo sapiens Murid gammaherpesvirus 4 Human betaherpesvirus 5 Rhadinovirus Human immunodeficiency virus 1 Human alphaherpesvirus 2 Human alphaherpesvirus 1 Betapolyomavirus hominis

PROVIDER: GSE42333 | GEO | 2014/12/31

SECONDARY ACCESSION(S): PRJNA181093

REPOSITORIES: GEO

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Effect of cigarette smoke extract, cisplatin, nicotine and/or ionizing radiation on gene expression in the NCI-H460 human lung large cell carcinoma cell line

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