Transcriptional profiling of Ewing's sarcoma derived exosomes
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ABSTRACT: Exosomes are small RNA and protein containing vesicles that can mediate hetero- and homotypic intercellular communication between normal and malignant cells. Especially, tumor-derived exosomes are believed to mediate reprogramming of the tumor-associated stroma to favor tumor growth and metastasis. In this study we isolated exosomes from three different Ewing’s sarcoma (ES) cell lines by ultracentrifugation. Microarray analysis of ES-derived exosomes and their parental cells was performed to gain insight into the spectrum of transcripts they contain and the functions in which these transcripts might be involved in.
ORGANISM(S): Homo sapiens
PROVIDER: GSE42282 | GEO | 2013/05/01
SECONDARY ACCESSION(S): PRJNA179529
REPOSITORIES: GEO
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