Transcriptomics

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Expression data from mouse lung treated with saline or bleomycin


ABSTRACT: Lung fibrosis represents the final common pathway of a variety of lung injuries, and it is characterized, independently of etiology, by the expansion of the fibroblast/myofibroblast population and by the abnormal accumulation of extracellular matrix (ECM) replacing normal functional parenchyma. In general, there is no effective therapy, and currently the only helpful available treatment for advanced lung fibrosis is transplantation. In this study we aimed to document the time-related reversibility of bleomycin-induced lung fibrosis, and to determine the gene expression patterns associated with the initial progression and the subsequent regression of the fibrotic response by microarray in this bleomycin mouse model of lung fibrosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE42301 | GEO | 2013/03/11

SECONDARY ACCESSION(S): PRJNA180999

REPOSITORIES: GEO

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