Transcriptomics

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Conversion of human fibroblast to endothelial cell by defined factors


ABSTRACT: Transient pluripotency-factor-based signaling-directed (TPS) transdifferentiation approach could be further applied to generate functional induced endothelial (iEnd) cells from human fibroblasts with only two factors: Oct4 and Klf4 (OK). The iEnd cells exhibit characteristic endothelial cell phenotype in vitro and in vivo and are capable of functionally promoting vascular regeneration and blood perfusion in a murine model of PAD.

ORGANISM(S): Homo sapiens

PROVIDER: GSE42672 | GEO | 2012/12/03

SECONDARY ACCESSION(S): PRJNA182702

REPOSITORIES: GEO

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