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Intracranial self-stimulation regulates gene expression in rat hippocampus

ABSTRACT: Transcriptional profiling of rat hippocampus 4.5h post intracranial self-stimulation (ICSS) show that this treatment, which improves learning and memory processes in a variety of paradigms of implicit and explicit memory, regulates gene expression of genes related to cAMP-mediated signaling and regulation of synaptic plasticity, among others. Rats were implanted with a monopolar stainless steel electrode aimed at the lateral hypothalamus in the right hemisphere. Hippocampal gene expression was analyzed 4.5h post treatment comparing rats subjected to acute self-stimulation (2500 stimulation trains; ICSS group) with sham-operated rats (with electrode placement but placed in the ICSS without stimulation during 40 min.; Sham group).

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE42793 | GEO | 2013/09/03

SECONDARY ACCESSION(S): PRJNA183164

REPOSITORIES: GEO

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Intracranial self-stimulation regulates gene expression in rat hippocampus

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