Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Progesterone Receptor Targetome in the Mammary Gland

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE42888 | GEO | 2013/08/27

SECONDARY ACCESSION(S): PRJNA183701

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Progesterone Receptor Targetome in the Mammary Gland

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-08-27 | E-GEOD-42888 | biostudies-arrayexpress

Research resource: progesterone receptor targetome underlying mammary gland branching morphogenesis.

Project description:Progesterone (P4)-activated progesterone receptors (PRs) play an essential role in driving pregnancy-associated mammary ductal side-branching morphogenesis and alveologenesis. However, the global cistromic and transcriptome responses that are required to elicit P4-dependent branching morphogenesis have not been elucidated. By combining chromatin immunoprecipitation followed by deep sequencing to identify genome-wide PR-binding sites in PR-positive luminal epithelial cells with global gene expression signatures acutely regulated by PRs in the mammary gland, we have identified a mammary epithelial PR targetome associated with active P4-dependent branching morphogenesis in vivo. We demonstrate that P4-induced side-branching is initiated by epithelial cell rearrangement into a multilayered epithelium that sprouts laterally from quiescent ducts via a mechanism requiring P4-dependent activation of Rac-GTPase signaling. We identify effectors of Rac-GTPases as direct transcriptional targets of PRs, and we demonstrate that disruption of the P4-activated Rac-GTPase signaling axis is sufficient to eliminate P4-dependent side-branching. Our data reveal that the molecular mediators of P4-dependent ductal side-branching overlap with those implicated in breast cancer.

| S-EPMC3787126 | biostudies-literature

Selective suppression of endothelial cytokine production by progesterone receptor

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-01-01 | E-GEOD-46503 | biostudies-arrayexpress

Physiological Vascular Permeability Requires Induction of Endothelial NR4A1 by Progesterone Receptor

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-01-01 | E-GEOD-43789 | biostudies-arrayexpress

Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-03-06 | E-GEOD-50518 | biostudies-arrayexpress

Progesterone receptor directs a distinct estrogen receptor-alpha chromatin binding profile in breast cancer to elicit good clinical outcome

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-05-22 | E-GEOD-68359 | biostudies-arrayexpress

Ulipristal and Progesterone Receptor

Project description:This SuperSeries is composed of the SubSeries listed below.

2012-10-04 | GSE37383 | GEO

Loss of EZH2 results in enhanced recruitment of EZH1, Pol II and Stat5 and precocious mammary gland development (SuperSeries)

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-01-27 | E-GEOD-65285 | biostudies-arrayexpress

ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signaling

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-08-19 | E-GEOD-47493 | biostudies-arrayexpress

Estrogen receptor-depended gene signatures and ER binding sites in the mouse mammary gland after acute estradiol treatment

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-07-23 | GSE130032 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data