Transcriptomics

Dataset Information

0

Expression data from immature dendritic cells (iDC) expressing HIV-1 Tat alleles and mutants


ABSTRACT: HIV-1 Tat induces the expression of interferon (IFN)-inducible genes in immature dendritic cells (iDC) in the absence of IFN production. We evaluated how three alleles of Tat and some Tat mutants differ in cellular gene modulation and whether a similar gene induction pattern could be detected by treating cells with IFN’s. The three alleles and mutants, with the exception of mutants TatSF21-47 and TatSF2G48-R57A that do not localize in the nucleous, modulated to different degrees IFN-inducible genes without concomitant induction of IFN’s. The first exon TatSF21-72 and the minimal transactivator TatSF21-58, all induced genes to a significantly greater extent than full-length Tat. The 2nd exon appears to diminish the gene modulation that can be observed when the first exon alone is expressed. We investigated the effect of various Tat alleles and mutants on host cell gene expression in immature dendritic cells (iDC). The cells were infected with adenoviruses expressing the Tat constructs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE42924 | GEO | 2013/06/01

SECONDARY ACCESSION(S): PRJNA183880

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-06-01 | E-GEOD-42924 | biostudies-arrayexpress
2013-06-01 | GSE42925 | GEO
2013-06-01 | E-GEOD-42925 | biostudies-arrayexpress
| PRJNA183880 | ENA
2013-05-31 | GSE42191 | GEO
2013-05-31 | E-GEOD-42191 | biostudies-arrayexpress
2009-02-01 | GSE10197 | GEO
2011-06-14 | E-GEOD-29944 | biostudies-arrayexpress
2015-03-20 | GSE67020 | GEO
2015-02-26 | GSE66301 | GEO