Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: NAYOUNG KIM
PROVIDER: E-GEOD-42191 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kim Nayoung N Kukkonen Sami S Martinez-Viedma Maria Del Pilar Mdel P Gupta Sumeet S Aldovini Anna A
Blood 20130327 20
As a result of its interaction with transcription factors, HIV type 1 (HIV-1) Tat can modulate the expression of both HIV and cellular genes. In antigen-presenting cells Tat induces the expression of a subset of interferon (IFN)-stimulated genes (ISGs) in the absence of IFNs. We investigated the genome-wide Tat association with promoters in immature dendritic cells and in monocyte-derived macrophages. Among others, Tat associated with the MAP2K6, MAP2K3, and IRF7 promoters that are functionally ...[more]