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Transcriptional and interactome network analyses of Substantia Nigra in progressive stages of Parkinson’s disease

ABSTRACT: We analyzed the transcriptomic profile of post-mortem substantia nigra explants from controls, intermediate - Braak 3 (BK3) and 4 (BK4) - stages of Parkinson’s disease in order to investigate how gene-gene interaction patterns vary along disease development. The comparative transcriptional networks analyses indicate that the main hubs in CT network showed less gene-gene connections in BK3 and BK4 networks, probably reflecting changes in SN cell metabolism, population and density along PD stages.

ORGANISM(S): Homo sapiens

PROVIDER: GSE42966 | GEO | 2018/11/30

REPOSITORIES: GEO

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| EGAS00001003065 | EGA

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