Nutrition-induced ketosis alters metabolic and signaling gene networks in liver of periparturient dairy cows
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ABSTRACT: Hepatic molecular adaptations underlying periparturient metabolic diseases such as ketosis in dairy cows are largely unknown. We used a simple model for induction of ketosis to examine liver gene expression profiles using a microarray consisting of 13,257 annotated cattle oligonucleotides. At 4 days post-partum, 7 cows classified as healthy after a physical examination were fed at 50% of intake at day 4 from day 5 to signs of ketosis or until 14 days post-partum. Another group of 7 healthy cows served as controls. Liver was biopsied at 9-14 (ketosis) or 14 days post-partum (controls). More than 9,000 sequences represented on the microarray were expressed in liver. Keywords: disease state analysis
ORGANISM(S): Bos taurus
PROVIDER: GSE4304 | GEO | 2007/10/09
SECONDARY ACCESSION(S): PRJNA94687
REPOSITORIES: GEO
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