Genomics

Dataset Information

0

The enhancer and promoter landscape of human regulatory and conventional T cell subpopulations


ABSTRACT: CD4+CD25+FOXP3+ human regulatory T cells (Treg) are essential for self-tolerance and immune homeostasis. Here, we generated genome-wide maps of poised and active enhancer elements marked by histone H3 lysine 4 monomethylation and histone H3 lysine 27 acetylation for CD4+CD25highCD45RA+ naive and CD4+CD25highCD45RA- memory Treg and their CD25- conventional T cell (Tconv) counterparts after in vitro expansion . In addition we generated genome-wide maps of the transcription factors STAT5, FOXP3, RUNX1 and ETS1 in expanded CD4+CD25highCD45RA+ Treg- and CD4+CD25- Tconv to elucidate their role in cell type-specific gene regulation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE43119 | GEO | 2014/04/01

SECONDARY ACCESSION(S): PRJNA185269

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-04-01 | E-GEOD-43119 | biostudies-arrayexpress
2011-01-31 | E-GEOD-26427 | biostudies-arrayexpress
2008-12-19 | E-GEOD-6813 | biostudies-arrayexpress
2010-05-19 | E-GEOD-14234 | biostudies-arrayexpress
2011-02-05 | E-GEOD-27082 | biostudies-arrayexpress
2015-04-30 | E-GEOD-61834 | biostudies-arrayexpress
2011-01-31 | GSE26427 | GEO
2009-05-20 | E-GEOD-14232 | biostudies-arrayexpress
2009-05-20 | GSE14234 | GEO
2018-03-15 | GSE111901 | GEO