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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): synthetic construct Homo sapiens

PROVIDER: GSE43179 | GEO | 2013/01/22

SECONDARY ACCESSION(S): PRJNA184850

REPOSITORIES: GEO

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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-01-22 | E-GEOD-43179 | biostudies-arrayexpress

MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP).

Project description:MicroRNA are small noncoding RNA molecules that regulate gene expression. To investigate the role of microRNA in immune thrombocytopenia (ITP), we performed genome-wide expression analyses of mRNA and microRNA in T cells from ITP patients and controls. We identified 1915 regulated genes and 22 regulated microRNA that differed between ITP patients and controls. Seventeen of the 22 regulated microRNA were linked to changes in target gene expression; 57 of these target genes were associated with the immune system, eg, T-cell activation and regulation of immunoglobulin production. CXCL13 and IL-21 were two microRNA target genes significantly increased in ITP. We could demonstrate increased plasma levels of CXCL13 and others have reported increased plasma levels of interleukin-21 in ITP. Thus, regulated microRNA were significantly associated with both gene and protein expression of molecules in immunological pathways. We suggest that microRNA may be important regulatory molecules involved in the loss of tolerance in ITP.

| S-EPMC3596969 | biostudies-literature

MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP) [miRNA]

Project description:MicroRNA are small non-coding RNA molecules that regulate gene expression. To investigate the role of microRNA in ITP, we performed genome-wide expression analyses of mRNA and microRNA in T-cells from ITP patients and controls. We identified 1,915 regulated genes and 22 regulated microRNA that differed between ITP patients and controls. Seventeen of the 22 regulated microRNA were linked to changes in target gene expression; 57 of these target genes were associated with the immune system, e.g. T-cell activation and regulation of immunoglobulin production. CXCL13 and IL-21 were two microRNA target genes significantly increased in ITP. We could demonstrate increased plasma levels of CXCL13 and others have reported increased plasma levels of IL-21 in ITP. Thus, regulated microRNA were significantly associated with both gene and protein expression of molecules in immunological pathways. We suggest that microRNA may be important regulatory molecules involved in the loss of tolerance in ITP. Microarray expression analysis of mRNA and miRNA in peripheral blood T-cell of control and ITP patients.

2013-01-22 | E-GEOD-43178 | biostudies-arrayexpress

MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP) [mRNA]

2013-01-22 | E-GEOD-43177 | biostudies-arrayexpress

MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP) [miRNA]

2013-01-22 | GSE43178 | GEO

MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP) [mRNA]

2013-01-22 | GSE43177 | GEO

MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

Project description:MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

| PRJNA184850 | ENA

MicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS)

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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MicroRNA regulate immune pathways in T-cells in multiple sclerosis (MS)

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-08-02 | GSE43592 | GEO

Pathogenesis and Therapeutic Mechanisms in Immune Thrombocytopenia (ITP).

Project description:Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated and/or T cell-mediated platelet destruction are key processes. In addition, impairment of T cells, cytokine imbalances, and the contribution of the bone marrow niche have now been recognized to be important. Treatment strategies are aimed at the restoration of platelet counts compatible with adequate hemostasis rather than achieving physiological platelet counts. The first line treatments focus on the inhibition of autoantibody production and platelet degradation, whereas second-line treatments include immunosuppressive drugs, such as Rituximab, and splenectomy. Finally, thirdline treatments aim to stimulate platelet production by megakaryocytes. This review discusses the pathophysiology of ITP and how the different treatment modalities affect the pathogenic mechanisms.

| S-EPMC5332920 | biostudies-other

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