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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP)

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Intawat Nookaew

PROVIDER: E-GEOD-43179 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNA regulate immunological pathways in T-cells in immune thrombocytopenia (ITP).

Jernås Margareta M Nookaew Intawat I Wadenvik Hans H Olsson Bob B

Blood 20130109 11

MicroRNA are small noncoding RNA molecules that regulate gene expression. To investigate the role of microRNA in immune thrombocytopenia (ITP), we performed genome-wide expression analyses of mRNA and microRNA in T cells from ITP patients and controls. We identified 1915 regulated genes and 22 regulated microRNA that differed between ITP patients and controls. Seventeen of the 22 regulated microRNA were linked to changes in target gene expression; 57 of these target genes were associated with th ...[more]

PMID: 23303824

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