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Genome-wide expression profiling of SGTA knockdown in C4-2B prostate cancer cells

ABSTRACT: Identifying the effect of the co-chaperone SGTA on global androgen receptor transcriptional activity in C4-2B prostate cancer cells with view to further elucidating the broader biological role of SGTA on other signaling pathways within prostate cancer cells Knockdown of SGTA for 72 hours in C4-2B cells significantly altered the expression of approximately 1900 genes in both vehicle and DHT treated cells. The effect of SGTA knockdown was to suppress the expression of approximately 60% of those transcripts. The regulation of 35% of DHT target genes was also affected by SGTA knockdown, with gene-specific effects on basal, or DHT-induced expression, or both.

ORGANISM(S): Homo sapiens

PROVIDER: GSE43521 | GEO | 2013/01/30

SECONDARY ACCESSION(S): PRJNA186640

REPOSITORIES: GEO

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Genome-wide expression profiling of SGTA knockdown in C4-2B prostate cancer cells

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