Expression data from mouse T cells after CLIP (Crosslinking immunoprecipitation) procedures (mRNA)

ABSTRACT: Molecular networks based on genome-wide mRNA and miRNA expression in activated T cells are interated by co-regulation with miRNA and protein-coding genes during immune responses, however, accurate prediction of miRs and their targets remains a challenge. Furthermore, the specific changes in the expression of miRNAs and/or mRNAs in allogeneic activated T cells during HCT would be distinct from those responding to non-specific stimulation. Recently, Ago-CLIP has been demonstrated to provide a robust platform for identification of precise miRNA-mRNA interactions by definitively distinguishing direct from indirect miRNA-target interactions. We utilized CLIP procedure followed by screening with standard microarray platforms for miRNA and mRNA transcripts to demonstrate the miR-mRNA landscape and identify novel molecular targets for modulating T cell responses.

ORGANISM(S): Mus musculus

PROVIDER: GSE43635 | GEO | 2013/01/19

SECONDARY ACCESSION(S): PRJNA186870

REPOSITORIES: GEO