DNA methylation in normal PC, MGUS, SMM and MM
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ABSTRACT: To characterize epigenomic changes during the transformation of normal plasma cells to myeloma, we used the HELP assay to analyze the methylome of CD138+ cells from 56 subjects representing premalignant (MGUS), early and advanced stages of myeloma as well as healthy controls. Plasma cells from premalignant and early stages of myeloma were characterized by striking, widespread hypomethylation.
ORGANISM(S): Homo sapiens
PROVIDER: GSE43860 | GEO | 2013/04/03
SECONDARY ACCESSION(S): PRJNA187924
REPOSITORIES: GEO
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