Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human CD138 purified bome marrow plasma cells from patients with mutliple myeloma or monoclonal gammopathy of unknown significance


ABSTRACT: Gene expression profiling of CD138 purified bone marrow plasma cells of previously untreated multiple myeloma patients and individual with monoclonal gammopathy of unknown significance (MGUS)

ORGANISM(S): Homo sapiens

DISEASE(S): monoclonal gammopathy of unknown significance (MGUS)

SUBMITTER: Dirk Hose 

PROVIDER: E-MTAB-317 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Annexin A2 (ANXA2) promotes myeloma cell growth, reduces apoptosis in myeloma cell lines, and increases osteoclast formation. ANXA2 has been described in small cohorts of samples as expressed by myeloma cells and cells of the BM microenvironment. To investigate its clinical role, we assessed 1148 samples including independent cohorts of 332 and 701 CD138-purified myeloma cell samples from previously untreated patients together with clinical prognostic factors, chromosomal aberrations, and gene e  ...[more]

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