Transcriptomics

Dataset Information

0

Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines

ABSTRACT: Abstract: BACKGROUND: The aim of this study was to characterize gene expression and DNA copy number profiles in androgen sensitive (AS) and androgen insensitive (AI) prostate cancer cell lines on a genome-wide scale. METHODS: Gene expression profiles and DNA copy number changes were examined using DNA microarrays in eight commonly used prostate cancer cell lines. Chromosomal regions with DNA copy number changes were identified using cluster along chromosome (CLAC). RESULTS: There were discrete differences in gene expression patterns between AS and AI cells that were not limited to androgen-responsive genes. AI cells displayed more DNA copy number changes, especially amplifications, than AS cells. The gene expression profiles of cell lines showed limited similarities to prostate tumors harvested at surgery. CONCLUSIONS: AS and AI cell lines are different in their transcriptional programs and degree of DNA copy number alterations. This dataset provides a context for the use of prostate cancer cell lines as models for clinical cancers. This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE4396 | GEO | 2006/03/08

SECONDARY ACCESSION(S): PRJNA94589

REPOSITORIES: GEO

Json Xml

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

Transcriptomics Gene expression variations in prostate cancer cell lines
2006-01-12 | GSE4016 | GEO
Genomics DNA copy number changes in prostate cancer cell lines
2006-01-12 | GSE4017 | GEO
Transcriptomics Genome-wide characterization of gene expression variations and DNA copy number changes in prostate cancer cell lines
2006-03-07 | E-GEOD-4396 | biostudies-arrayexpress
Transcriptomics DNA copy number changes in prostate cancer cell lines
2006-01-11 | E-GEOD-4017 | biostudies-arrayexpress
Transcriptomics Differential gene expression profiles between two novel murine prostate cancer cell lines derived from androgen‑dependent (PLum‑AD cells) and androgen‑independent (PLum‑AI cells) prostate cancer
2020-05-27 | GSE151187 | GEO
Genomics Homo sapiens
| PRJNA104595 | ENA
Methylation profiling DNA methylation profile of Prostate Cancer cell lines
2023-12-31 | GSE217962 | GEO
Transcriptomics lncRNA-PCAT1 knockdown effect on the gene expression of androgen independent LNCaP (LNCaP-AI) cell line
2019-01-01 | GSE124519 | GEO
Genomics DNA copy number alteration analysis of radioresistant and radiosensitive prostate cancer cell lines
| PRJNA555346 | ENA
Genomics DNA copy number alteration analysis and gene expression profiles comparing radioresistant to radiosensitive prostate cancer cell lines
| PRJNA555334 | ENA