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Identification of genes involved in SHH subgroup medulloblastoma using murine whole-body Sleeping Beauty insertional mutagenesis

ABSTRACT: Ptch+/- mice, which are predisposed to SHH subgroup medulloblastoma, were mutagenised using the Sleeping Beauty transposon to identify genes which increase the frequency of medulloblastoma formation. Gene expression in tumours was assessed both to investigate their relationship to human subgroup tumours, and to identify genes where expression was altered by mutagenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE43994 | GEO | 2013/07/09

SECONDARY ACCESSION(S): PRJNA188311

REPOSITORIES: GEO

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