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Genome-scale DNA methylation maps of mouse chromaffin cells with or without Sdhb knock-out.

ABSTRACT: We report the analysis of DNA methylation in mouse chromaffin cell lines using reduced representation bisulfite sequencing (RRBS). We compared DNA methylation profiles of cell lines with or without a knock-out of Sdhb gene, showing that Sdhb disruption results in a hypermethylator phenotype.

ORGANISM(S): Mus musculus

PROVIDER: GSE44350 | GEO | 2013/05/06

SECONDARY ACCESSION(S): PRJNA189668

REPOSITORIES: GEO

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Genome-scale DNA methylation maps of mouse chromaffin cells with or without Sdhb knock-out.

Project description:We report the analysis of DNA methylation in mouse chromaffin cell lines using reduced representation bisulfite sequencing (RRBS). We compared DNA methylation profiles of cell lines with or without a knock-out of Sdhb gene, showing that Sdhb disruption results in a hypermethylator phenotype. Reduced representation bisulfite sequencing of 4 mouse chromaffin cell samples (2 Sdhb wild-type and 2 Sdhb knock-out).

2013-05-06 | E-GEOD-44350 | biostudies-arrayexpress

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Cells silenced for SDHB expression and tumor phenotype

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