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The effect of Sparstolonin B (SsnB) on gene expression in HCAECs

ABSTRACT: Sparstolonin B is a novel bioactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. SsnB has previously demonstrated anti-angiogenic properties. In functional assays, SsnB inhibited endothelial cell tube formation (Matrigel method) and cell migration (Transwell method) in a dose-dependent manner. We used microarrays to examine how SsnB affected the gene expression of human coronary artery endothelial cells (HCAECs), focusing in particular on pathways related to angiogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE44596 | GEO | 2014/02/20

SECONDARY ACCESSION(S): PRJNA190903

REPOSITORIES: GEO

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The effect of Sparstolonin B (SsnB) on gene expression in HCAECs

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