Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Henry Bateman
PROVIDER: E-GEOD-44596 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bateman Henry R HR Liang Qiaoli Q Fan Daping D Rodriguez Vanessa V Lessner Susan M SM
PloS one 20130805 8
Sparstolonin B (SsnB) is a novel bioactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. Angiogenesis, the process of new capillary formation from existing blood vessels, is dysregulated in many pathological disorders, including diabetic retinopathy, tumor growth, and atherosclerosis. In functional assays, SsnB inhibited endothelial cell tube formation (Matrigel method) and cell migration (Transwell method) in a ...[more]